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- Title
Bellerophontes: an RNA-Seq data analysis framework for chimeric transcripts discovery based on accurate fusion model.
- Authors
Abate, Francesco; Acquaviva, Andrea; Paciello, Giulia; Foti, Carmelo; Ficarra, Elisa; Ferrarini, Alberto; Delledonne, Massimo; Iacobucci, Ilaria; Soverini, Simona; Martinelli, Giovanni; Macii, Enrico
- Abstract
Next-generation sequencing technology allows the detection of genomic structural variations, novel genes and transcript isoforms from the analysis of high-throughput data. In this work, we propose a new framework for the detection of fusion transcripts through short paired-end reads which integrates splicing-driven alignment and abundance estimation analysis, producing a more accurate set of reads supporting the junction discovery and taking into account also not annotated transcripts. Bellerophontes performs a selection of putative junctions on the basis of a match to an accurate gene fusion model.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 16, p2114
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts334