We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genomic dark matter: the reliability of short read mapping illustrated by the genome mappability score.
- Authors
Lee, Hayan; Schatz, Michael C
- Abstract
Genome resequencing and short read mapping are two of the primary tools of genomics and are used for many important applications. The current state-of-the-art in mapping uses the quality values and mapping quality scores to evaluate the reliability of the mapping. These attributes, however, are assigned to individual reads and do not directly measure the problematic repeats across the genome. Here, we present the Genome Mappability Score (GMS) as a novel measure of the complexity of resequencing a genome. The GMS is a weighted probability that any read could be unambiguously mapped to a given position and thus measures the overall composition of the genome itself.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 16, p2097
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts330