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- Title
Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs.
- Authors
Saunders, Christopher T; Wong, Wendy S W; Swamy, Sajani; Becq, Jennifer; Murray, Lisa J; Cheetham, R Keira
- Abstract
Whole genome and exome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. The consequent increased demand for somatic variant analysis of paired samples requires methods specialized to model this problem so as to sensitively call variants at any practical level of tumor impurity.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 14, p1811
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts271