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- Title
Gencrypt: one-way cryptographic hashes to detect overlapping individuals across samples.
- Authors
Turchin, Michael C; Hirschhorn, Joel N
- Abstract
Meta-analysis across genome-wide association studies is a common approach for discovering genetic associations. However, in some meta-analysis efforts, individual-level data cannot be broadly shared by study investigators due to privacy and Institutional Review Board concerns. In such cases, researchers cannot confirm that each study represents a unique group of people, leading to potentially inflated test statistics and false positives. To resolve this problem, we created a software tool, Gencrypt, which utilizes a security protocol known as one-way cryptographic hashes to allow overlapping participants to be identified without sharing individual-level data.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 6, p886
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts045