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- Title
Estimation of pairwise sequence similarity of mammalian enhancers with word neighbourhood counts.
- Authors
Göke, Jonathan; Schulz, Marcel H; Lasserre, Julia; Vingron, Martin
- Abstract
The identity of cells and tissues is to a large degree governed by transcriptional regulation. A major part is accomplished by the combinatorial binding of transcription factors at regulatory sequences, such as enhancers. Even though binding of transcription factors is sequence-specific, estimating the sequence similarity of two functionally similar enhancers is very difficult. However, a similarity measure for regulatory sequences is crucial to detect and understand functional similarities between two enhancers and will facilitate large-scale analyses like clustering, prediction and classification of genome-wide datasets.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 5, p656
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/bts028