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- Title
PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data.
- Authors
Zhang, Yanju; Lameijer, Eric-Wubbo; 't Hoen, Peter A C; Ning, Zemin; Slagboom, P Eline; Ye, Kai
- Abstract
RNA-seq is a powerful technology for the study of transcriptome profiles that uses deep-sequencing technologies. Moreover, it may be used for cellular phenotyping and help establishing the etiology of diseases characterized by abnormal splicing patterns. In RNA-Seq, the exact nature of splicing events is buried in the reads that span exon-exon boundaries. The accurate and efficient mapping of these reads to the reference genome is a major challenge.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 4, p479
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr712