We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identifying quantitative trait loci via group-sparse multitask regression and feature selection: an imaging genetics study of the ADNI cohort.
- Authors
Wang, Hua; Nie, Feiping; Huang, Heng; Kim, Sungeun; Nho, Kwangsik; Risacher, Shannon L; Saykin, Andrew J; Shen, Li; Alzheimer's Disease Neuroimaging Initiative
- Abstract
Recent advances in high-throughput genotyping and brain imaging techniques enable new approaches to study the influence of genetic variation on brain structures and functions. Traditional association studies typically employ independent and pairwise univariate analysis, which treats single nucleotide polymorphisms (SNPs) and quantitative traits (QTs) as isolated units and ignores important underlying interacting relationships between the units. New methods are proposed here to overcome this limitation.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 2, p229
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr649