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- Title
Discovering transcription factor regulatory targets using gene expression and binding data.
- Authors
Maienschein-Cline, Mark; Zhou, Jie; White, Kevin P; Sciammas, Roger; Dinner, Aaron R
- Abstract
Identifying the target genes regulated by transcription factors (TFs) is the most basic step in understanding gene regulation. Recent advances in high-throughput sequencing technology, together with chromatin immunoprecipitation (ChIP), enable mapping TF binding sites genome wide, but it is not possible to infer function from binding alone. This is especially true in mammalian systems, where regulation often occurs through long-range enhancers in gene-rich neighborhoods, rather than proximal promoters, preventing straightforward assignment of a binding site to a target gene.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 2, p206
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr628