We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
deepBlockAlign: a tool for aligning RNA-seq profiles of read block patterns.
- Authors
Langenberger, David; Pundhir, Sachin; Ekstrøm, Claus T; Stadler, Peter F; Hoffmann, Steve; Gorodkin, Jan
- Abstract
High-throughput sequencing methods allow whole transcriptomes to be sequenced fast and cost-effectively. Short RNA sequencing provides not only quantitative expression data but also an opportunity to identify novel coding and non-coding RNAs. Many long transcripts undergo post-transcriptional processing that generates short RNA sequence fragments. Mapped back to a reference genome, they form distinctive patterns that convey information on both the structure of the parent transcript and the modalities of its processing. The miR-miR* pattern from microRNA precursors is the best-known, but by no means singular, example.
- Publication
Bioinformatics (Oxford, England), 2012, Vol 28, Issue 1, p17
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr598