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- Title
FLASH: fast length adjustment of short reads to improve genome assemblies.
- Authors
Magoč, Tanja; Salzberg, Steven L
- Abstract
Next-generation sequencing technologies generate very large numbers of short reads. Even with very deep genome coverage, short read lengths cause problems in de novo assemblies. The use of paired-end libraries with a fragment size shorter than twice the read length provides an opportunity to generate much longer reads by overlapping and merging read pairs before assembling a genome.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 21, p2957
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr507