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Title
Bayesian prediction of tissue-regulated splicing using RNA sequence and cellular context.
Authors
Xiong, Hui Yuan; Barash, Yoseph; Frey, Brendan J
Abstract
Alternative splicing is a major contributor to cellular diversity in mammalian tissues and relates to many human diseases. An important goal in understanding this phenomenon is to infer a 'splicing code' that predicts how splicing is regulated in different cell types by features derived from RNA, DNA and epigenetic modifiers.