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- Title
Aligning short reads to reference alignments and trees.
- Authors
Berger, Simon A; Stamatakis, Alexandros
- Abstract
Likelihood-based methods for placing short read sequences from metagenomic samples into reference phylogenies have been recently introduced. At present, it is unclear how to align those reads with respect to the reference alignment that was deployed to infer the reference phylogeny. Moreover, the adaptability of such alignment methods with respect to the underlying reference alignment strategies/philosophies has not been explored. It has also not been assessed if the reference phylogeny can be deployed in conjunction with the reference alignment to improve alignment accuracy in this context.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 15, p2068
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr320