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- Title
FusionMap: detecting fusion genes from next-generation sequencing data at base-pair resolution.
- Authors
Ge, Huanying; Liu, Kejun; Juan, Todd; Fang, Fang; Newman, Matthew; Hoeck, Wolfgang
- Abstract
Next generation sequencing technology generates high-throughput data, which allows us to detect fusion genes at both transcript and genomic levels. To detect fusion genes, the current bioinformatics tools heavily rely on paired-end approaches and overlook the importance of reads that span fusion junctions. Thus there is a need to develop an efficient aligner to detect fusion events by accurate mapping of these junction-spanning single reads, particularly when the read gets longer with the improvement in sequencing technology.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 14, p1922
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr310