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- Title
Model building and intelligent acquisition with application to protein subcellular location classification.
- Authors
Jackson, C; Glory-Afshar, E; Murphy, R F; Kovacevic, J
- Abstract
We present a framework and algorithms to intelligently acquire movies of protein subcellular location patterns by learning their models as they are being acquired, and simultaneously determining how many cells to acquire as well as how many frames to acquire per cell. This is motivated by the desire to minimize acquisition time and photobleaching, given the need to build such models for all proteins, in all cell types, under all conditions. Our key innovation is to build models during acquisition rather than as a post-processing step, thus allowing us to intelligently and automatically adapt the acquisition process given the model acquired.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 13, p1854
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr286