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- Title
BINOCh: binding inference from nucleosome occupancy changes.
- Authors
Meyer, Clifford A; He, Housheng H; Brown, Myles; Liu, X Shirley
- Abstract
Transcription factor binding events are frequently associated with a pattern of nucleosome occupancy changes in which nucleosomes flanking the binding site increase in occupancy, while those in the vicinity of the binding site itself are displaced. Genome-wide information on enhancer proximal nucleosome occupancy can be readily acquired using ChIP-seq targeting enhancer-related histone modifications such as H3K4me2. Here, we present a software package, BINOCh that allows biologists to use such data to infer the identity of key transcription factors that regulate the response of a cell to a stimulus or determine a program of differentiation.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 13, p1867
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr279