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- Title
Pathway analysis of high-throughput biological data within a Bayesian network framework.
- Authors
Isci, Senol; Ozturk, Cengizhan; Jones, Jon; Otu, Hasan H
- Abstract
Most current approaches to high-throughput biological data (HTBD) analysis either perform individual gene/protein analysis or, gene/protein set enrichment analysis for a list of biologically relevant molecules. Bayesian Networks (BNs) capture linear and non-linear interactions, handle stochastic events accounting for noise, and focus on local interactions, which can be related to causal inference. Here, we describe for the first time an algorithm that models biological pathways as BNs and identifies pathways that best explain given HTBD by scoring fitness of each network.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 12, p1667
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr269