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- Title
PhyloCSF: a comparative genomics method to distinguish protein coding and non-coding regions.
- Authors
Lin, Michael F; Jungreis, Irwin; Kellis, Manolis
- Abstract
As high-throughput transcriptome sequencing provides evidence for novel transcripts in many species, there is a renewed need for accurate methods to classify small genomic regions as protein coding or non-coding. We present PhyloCSF, a novel comparative genomics method that analyzes a multispecies nucleotide sequence alignment to determine whether it is likely to represent a conserved protein-coding region, based on a formal statistical comparison of phylogenetic codon models.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 13, pi275
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr209