We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Sensitive gene fusion detection using ambiguously mapping RNA-Seq read pairs.
- Authors
Kinsella, Marcus; Harismendy, Olivier; Nakano, Masakazu; Frazer, Kelly A; Bafna, Vineet
- Abstract
Paired-end whole transcriptome sequencing provides evidence for fusion transcripts. However, due to the repetitiveness of the transcriptome, many reads have multiple high-quality mappings. Previous methods to find gene fusions either ignored these reads or required additional longer single reads. This can obscure up to 30% of fusions and unnecessarily discards much of the data.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 8, p1068
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btr085