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Title
Identifying cancer driver genes in tumor genome sequencing studies.
Authors
Youn, Ahrim; Simon, Richard
Abstract
Major tumor sequencing projects have been conducted in the past few years to identify genes that contain 'driver' somatic mutations in tumor samples. These genes have been defined as those for which the non-silent mutation rate is significantly greater than a background mutation rate estimated from silent mutations. Several methods have been used for estimating the background mutation rate.