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- Title
Assigning duplication events to relative temporal scales in genome-wide studies.
- Authors
Huerta-Cepas, Jaime; Gabaldón, Toni
- Abstract
In genome-wide analyses, the relative age of gene duplications is often estimated by measuring the rate of synonymous substitutions (dS) between paralogous sequences. On the other hand, recent studies have shown the feasibility of inferring, at genomic scales, the relative age of duplication events from the topology of gene family trees. This represents a promising alternative for large surveys requiring an automatic methodology to establish a timeline of duplication events and that are usually limited to the use of dS, which presents known limitations such as a fast saturation of the signal. However, both measures have never been compared in a common framework.
- Publication
Bioinformatics (Oxford, England), 2011, Vol 27, Issue 1, p38
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq609