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- Title
Semi-supervised recursively partitioned mixture models for identifying cancer subtypes.
- Authors
Koestler, Devin C; Marsit, Carmen J; Christensen, Brock C; Karagas, Margaret R; Bueno, Raphael; Sugarbaker, David J; Kelsey, Karl T; Houseman, E Andres
- Abstract
Patients with identical cancer diagnoses often progress differently. The disparity we see in disease progression and treatment response can be attributed to the idea that two histologically similar cancers may be completely different diseases on the molecular level. Methods for identifying cancer subtypes associated with patient survival have the capacity to be powerful instruments for understanding the biochemical processes that underlie disease progression as well as providing an initial step toward more personalized therapy for cancer patients. We propose a method called semi-supervised recursively partitioned mixture models (SS-RPMM) that utilizes array-based genetic and patient-level clinical data for finding cancer subtypes that are associated with patient survival.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 20, p2578
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq470