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- Title
Reptile: representative tiling for short read error correction.
- Authors
Yang, Xiao; Dorman, Karin S; Aluru, Srinivas
- Abstract
Error correction is critical to the success of next-generation sequencing applications, such as resequencing and de novo genome sequencing. It is especially important for high-throughput short-read sequencing, where reads are much shorter and more abundant, and errors more frequent than in traditional Sanger sequencing. Processing massive numbers of short reads with existing error correction methods is both compute and memory intensive, yet the results are far from satisfactory when applied to real datasets.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 20, p2526
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq468