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- Title
A probabilistic framework for aligning paired-end RNA-seq data.
- Authors
Yin Hu; Kai Wang; Xiaping He; Chiang, Derek Y.; Prins, Jan F.; Jinze Liu
- Abstract
Motivation: The RNA-seq paired-end read (PER) protocol samples transcript fragments longer than the sequencing capability of today's technology by sequencing just the two ends of each fragment. Deep sampling of the transcriptome using the PER protocol presents the opportunity to reconstruct the unsequenced portion of each transcript fragment using end reads from overlapping PERs, guided by the expected length of the fragment.
- Publication
Bioinformatics, 2010, Vol 26, Issue 16, p1950
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btq336