We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Structure-based kernels for the prediction of catalytic residues and their involvement in human inherited disease.
- Authors
Fuxiao Xin; Myers, Steven; Yong Fuga Li; Cooper, David N.; Mooney, Sean D.; Radivojac, Predrag
- Abstract
Motivation: Enzyme catalysis is involved in numerous biological processes and the disruption of enzymatic activity has been implicated in human disease. Despite this, various aspects of catalytic reactions are not completely understood, such as the mechanics of reaction chemistry and the geometry of catalytic residues within active sites. As a result, the computational prediction of catalytic residues has the potential to identify novel catalytic pockets, aid in the design of more efficient enzymes and also predict the molecular basis of disease.
- Publication
Bioinformatics, 2010, Vol 26, Issue 16, p1975
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btq319