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- Title
ACNE: a summarization method to estimate allele-specific copy numbers for Affymetrix SNP arrays.
- Authors
Ortiz-Estevez, Maria; Bengtsson, Henrik; Rubio, Angel
- Abstract
Current algorithms for estimating DNA copy numbers (CNs) borrow concepts from gene expression analysis methods. However, single nucleotide polymorphism (SNP) arrays have special characteristics that, if taken into account, can improve the overall performance. For example, cross hybridization between alleles occurs in SNP probe pairs. In addition, most of the current CN methods are focused on total CNs, while it has been shown that allele-specific CNs are of paramount importance for some studies. Therefore, we have developed a summarization method that estimates high-quality allele-specific CNs.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 15, p1827
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq300