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- Title
Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM.
- Authors
Vaske, Charles J; Benz, Stephen C; Sanborn, J Zachary; Earl, Dent; Szeto, Christopher; Zhu, Jingchun; Haussler, David; Stuart, Joshua M
- Abstract
High-throughput data is providing a comprehensive view of the molecular changes in cancer tissues. New technologies allow for the simultaneous genome-wide assay of the state of genome copy number variation, gene expression, DNA methylation and epigenetics of tumor samples and cancer cell lines. Analyses of current data sets find that genetic alterations between patients can differ but often involve common pathways. It is therefore critical to identify relevant pathways involved in cancer progression and detect how they are altered in different patients.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 12, pi237
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq182