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- Title
Structural variation analysis with strobe reads.
- Authors
Ritz, Anna; Bashir, Ali; Raphael, Benjamin J
- Abstract
Structural variation including deletions, duplications and rearrangements of DNA sequence are an important contributor to genome variation in many organisms. In human, many structural variants are found in complex and highly repetitive regions of the genome making their identification difficult. A new sequencing technology called strobe sequencing generates strobe reads containing multiple subreads from a single contiguous fragment of DNA. Strobe reads thus generalize the concept of paired reads, or mate pairs, that have been routinely used for structural variant detection. Strobe sequencing holds promise for unraveling complex variants that have been difficult to characterize with current sequencing technologies.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 10, p1291
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq153