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- Title
SoDA2: a Hidden Markov Model approach for identification of immunoglobulin rearrangements.
- Authors
Munshaw, Supriya; Kepler, Thomas B
- Abstract
The inference of pre-mutation immunoglobulin (Ig) rearrangements is essential in the study of the antibody repertoires produced in response to infection, in B-cell neoplasms and in autoimmune disease. Often, there are several rearrangements that are nearly equivalent as candidates for a given Ig gene, but have different consequences in an analysis. Our aim in this article is to develop a probabilistic model of the rearrangement process and a Bayesian method for estimating posterior probabilities for the comparison of multiple plausible rearrangements.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 7, p867
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btq056