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- Title
Simulation-based model selection for dynamical systems in systems and population biology.
- Authors
Toni, Tina; Stumpf, Michael P H
- Abstract
Computer simulations have become an important tool across the biomedical sciences and beyond. For many important problems several different models or hypotheses exist and choosing which one best describes reality or observed data is not straightforward. We therefore require suitable statistical tools that allow us to choose rationally between different mechanistic models of, e.g. signal transduction or gene regulation networks. This is particularly challenging in systems biology where only a small number of molecular species can be assayed at any given time and all measurements are subject to measurement uncertainty.
- Publication
Bioinformatics (Oxford, England), 2010, Vol 26, Issue 1, p104
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp619