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- Title
Detailing regulatory networks through large scale data integration.
- Authors
Huttenhower, Curtis; Mutungu, K Tsheko; Indik, Natasha; Yang, Woongcheol; Schroeder, Mark; Forman, Joshua J; Troyanskaya, Olga G; Coller, Hilary A
- Abstract
Much of a cell's regulatory response to changing environments occurs at the transcriptional level. Particularly in higher organisms, transcription factors (TFs), microRNAs and epigenetic modifications can combine to form a complex regulatory network. Part of this system can be modeled as a collection of regulatory modules: co-regulated genes, the conditions under which they are co-regulated and sequence-level regulatory motifs.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 24, p3267
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp588