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- Title
Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data.
- Authors
Degner, Jacob F; Marioni, John C; Pai, Athma A; Pickrell, Joseph K; Nkadori, Everlyne; Gilad, Yoav; Pritchard, Jonathan K
- Abstract
Next-generation sequencing has become an important tool for genome-wide quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short sequence reads back to their correct locations in a reference genome. Here, we investigate the impact of SNP variation on the reliability of read-mapping in the context of detecting allele-specific expression (ASE).
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 24, p3207
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp579