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- Title
EasyMIFS and SiteHound: a toolkit for the identification of ligand-binding sites in protein structures.
- Authors
Ghersi, Dario; Sanchez, Roberto
- Abstract
SiteHound uses Molecular Interaction Fields (MIFs) produced by EasyMIFs to identify protein structure regions that show a high propensity for interaction with ligands. The type of binding site identified depends on the probe atom used in the MIF calculation. The input to EasyMIFs is a PDB file of a protein structure; the output MIF serves as input to SiteHound, which in turn produces a list of putative binding sites. Extensive testing of SiteHound for the detection of binding sites for drug-like molecules and phosphorylated ligands has been carried out.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 23, p3185
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp562