We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
An optimization model for metabolic pathways.
- Authors
Planes, F J; Beasley, J E
- Abstract
Different mathematical methods have emerged in the post-genomic era to determine metabolic pathways. These methods can be divided into stoichiometric methods and path finding methods. In this paper we detail a novel optimization model, based upon integer linear programming, to determine metabolic pathways. Our model links reaction stoichiometry with path finding in a single approach. We test the ability of our model to determine 40 annotated Escherichia coli metabolic pathways. We show that our model is able to determine 36 of these 40 pathways in a computationally effective manner.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 20, p2723
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp441