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- Title
The impact of incomplete knowledge on evaluation: an experimental benchmark for protein function prediction.
- Authors
Huttenhower, Curtis; Hibbs, Matthew A; Myers, Chad L; Caudy, Amy A; Hess, David C; Troyanskaya, Olga G
- Abstract
Rapidly expanding repositories of highly informative genomic data have generated increasing interest in methods for protein function prediction and inference of biological networks. The successful application of supervised machine learning to these tasks requires a gold standard for protein function: a trusted set of correct examples, which can be used to assess performance through cross-validation or other statistical approaches. Since gene annotation is incomplete for even the best studied model organisms, the biological reliability of such evaluations may be called into question.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 18, p2404
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp397