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- Title
Comparative study on ChIP-seq data: normalization and binding pattern characterization.
- Authors
Taslim, Cenny; Wu, Jiejun; Yan, Pearlly; Singer, Greg; Parvin, Jeffrey; Huang, Tim; Lin, Shili; Huang, Kun
- Abstract
Antibody-based Chromatin Immunoprecipitation assay followed by high-throughput sequencing technology (ChIP-seq) is a relatively new method to study the binding patterns of specific protein molecules over the entire genome. ChIP-seq technology allows scientist to get more comprehensive results in shorter time. Here, we present a non-linear normalization algorithm and a mixture modeling method for comparing ChIP-seq data from multiple samples and characterizing genes based on their RNA polymerase II (Pol II) binding patterns.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 18, p2334
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp384