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- Title
ISOLATE: a computational strategy for identifying the primary origin of cancers using high-throughput sequencing.
- Authors
Quon, Gerald; Morris, Quaid
- Abstract
One of the most deadly cancer diagnoses is the carcinoma of unknown primary origin. Without the knowledge of the site of origin, treatment regimens are limited in their specificity and result in high mortality rates. Though supervised classification methods have been developed to predict the site of origin based on gene expression data, they require large numbers of previously classified tumors for training, in part because they do not account for sample heterogeneity, which limits their application to well-studied cancers.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 21, p2882
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp378