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- Title
Copy number variation has little impact on bead-array-based measures of DNA methylation.
- Authors
Houseman, E Andrés; Christensen, Brock C; Karagas, Margaret R; Wrensch, Margaret R; Nelson, Heather H; Wiemels, Joseph L; Zheng, Shichun; Wiencke, John K; Kelsey, Karl T; Marsit, Carmen J
- Abstract
Integration of various genome-scale measures of molecular alterations is of great interest to researchers aiming to better define disease processes or identify novel targets with clinical utility. Particularly important in cancer are measures of gene copy number DNA methylation. However, copy number variation may bias the measurement of DNA methylation. To investigate possible bias, we analyzed integrated data obtained from 19 head and neck squamous cell carcinoma (HNSCC) tumors and 23 mesothelioma tumors.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 16, p1999
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp364