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- Title
Fast and accurate short read alignment with Burrows-Wheeler transform.
- Authors
Li, Heng; Durbin, Richard
- Abstract
The enormous amount of short reads generated by the new DNA sequencing technologies call for the development of fast and accurate read alignment programs. A first generation of hash table-based methods has been developed, including MAQ, which is accurate, feature rich and fast enough to align short reads from a single individual. However, MAQ does not support gapped alignment for single-end reads, which makes it unsuitable for alignment of longer reads where indels may occur frequently. The speed of MAQ is also a concern when the alignment is scaled up to the resequencing of hundreds of individuals.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 14, p1754
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btp324