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- Title
FlexServ: an integrated tool for the analysis of protein flexibility.
- Authors
Jordi Camps; Oliver Carrillo; Agustí Emperador; Laura Orellana; Adam Hospital; Manuel Rueda; Damjan Cicin-Sain; Marco DAbramo; Josep Lluís Gelpí; Modesto Orozco
- Abstract
Summary: FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemanns indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics. Availability: http://mmb.pcb.ub.es/FlexServ; http://www.inab.org Contact: modesto@mmb.pcb.ub.es or gelpi@mmb.pcb.ub.es Supplementary information: Additional information and methodology details can be found at http://mmb.pcb.ub.es/FlexServ/help.
- Publication
Bioinformatics, 2009, Vol 25, Issue 13, p1709
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btp304