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- Title
Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
- Authors
Björn Nilsson; Mikael Johansson; Fatima Al-Shahrour; Anne E. Carpenter; Benjamin L. Ebert
- Abstract
Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy. Availability: www.broad.mit.edu/ultrasome. Contact: bnilsson@broad.mit.edu Supplementary information: Supplementary data are available at Bioinformatics online.
- Publication
Bioinformatics, 2009, Vol 25, Issue 8, p1078
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btp091