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- Title
Predicting DNA recognition by Cys2His2 zinc finger proteins.
- Authors
Persikov, Anton V; Osada, Robert; Singh, Mona
- Abstract
Cys(2)His(2) zinc finger (ZF) proteins represent the largest class of eukaryotic transcription factors. Their modular structure and well-conserved protein-DNA interface allow the development of computational approaches for predicting their DNA-binding preferences even when no binding sites are known for a particular protein. The 'canonical model' for ZF protein-DNA interaction consists of only four amino acid nucleotide contacts per zinc finger domain.
- Publication
Bioinformatics (Oxford, England), 2009, Vol 25, Issue 1, p22
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btn580