We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Discovering regulatory motifs in the Plasmodium genome using comparative genomics.
- Authors
Jie Wu; Sieglaff, Douglas H.; Gervin, Joshua; Xie, Xiaohui S.
- Abstract
Motivation: Understanding gene regulation in Plasmodium, the causative agent of malaria, is an important step in deciphering its complex life cycle as well as leading to possible new targets for therapeutic applications. Very little is known about gene regulation in Plasmodium, and in particular, few regulatory elements have been identified. Such discovery has been significantly hampered by the high A-T content of some of the genomes of Plasmodium species, as well as the challenge in associating discovered regulatory elements to gene regulatory cascades due to Plasmodium's complex life cycle.
- Publication
Bioinformatics, 2008, Vol 24, Issue 17, p1843
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btn348