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- Title
GAzer: gene set analyzer.
- Authors
Sang-Bae Kim; Sungjin Yang; Seon-Kyu Kim; Sang Cheol Kim; Hyun Goo Woo; David J. Volsky; Seon-Young Kim; In-Sun Chu
- Abstract
Summary: Gene Set Analyzer (GAzer) is a web-based integrated gene set analysis tool covering previously reported parametric and non-parametric models. Based on a simulation test for the reported algorithms, we classified and implemented three main statistical methods consisting of the z-statistic, gene permutation and sample permutation for ten gene set categories including Gene Ontology (GO) for human, mouse, rat and yeast. This tool identifies significantly altered gene sets scored by z-statistics and P-values from the z-test or permutation test and provides q-values and Bonferroni P-values to correct multiple hypothesis testing. GAzer allows users to observe changes in expression of each gene in a gene set or to see the significance of the gene sets containing a gene(s) of interest, thus allowing interactive data analysis both at the gene and gene set level. Moreover, GAzer offers extensive annotation for each gene. Availability: The GAzer gene set analyzer is freely available at http://integromics.kobic.re.kr/GAzer/ Contact: kimsy@kribb.re.kr and chu@kribb.re.kr Supplementary information: This can be found on the web page (http://integromics.kobic.re.kr/GAzer/supplement.jsp)
- Publication
Bioinformatics, 2007, Vol 23, Issue 13, p1697
- ISSN
1367-4803
- Publication type
Academic Journal
- DOI
10.1093/bioinformatics/btm144