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- Title
Maximum likelihood inference of imprinting and allele-specific expression from EST data.
- Authors
Seoighe, Cathal; Nembaware, Victoria; Scheffler, Konrad
- Abstract
In a diploid organism the proportion of transcripts that are produced from the two parental alleles can differ substantially due, for example to epigenetic modification that causes complete or partial silencing of one parental allele or to cis acting polymorphisms that affect transcriptional regulation. Counts of SNP alleles derived from EST sequences have been used to identify both novel candidates for genomic imprinting as well as examples of genes with allelic differences in expression.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 24, p3032
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl521