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- Title
Measuring covariation in RNA alignments: physical realism improves information measures.
- Authors
Lindgreen, S; Gardner, P P; Krogh, A
- Abstract
The importance of non-coding RNAs is becoming increasingly evident, and often the function of these molecules depends on the structure. It is common to use alignments of related RNA sequences to deduce the consensus secondary structure by detecting patterns of co-evolution. A central part of such an analysis is to measure covariation between two positions in an alignment. Here, we rank various measures ranging from simple mutual information to more advanced covariation measures.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 24, p2988
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl514