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- Title
Discovering disease-genes by topological features in human protein-protein interaction network.
- Authors
Xu, Jianzhen; Li, Yongjin
- Abstract
Mining the hereditary disease-genes from human genome is one of the most important tasks in bioinformatics research. A variety of sequence features and functional similarities between known human hereditary disease-genes and those not known to be involved in disease have been systematically examined and efficient classifiers have been constructed based on the identified common patterns. The availability of human genome-wide protein-protein interactions (PPIs) provides us with new opportunity for discovering hereditary disease-genes by topological features in PPIs network.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 22, p2800
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl467