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- Title
MARD: a new method to detect differential gene expression in treatment-control time courses.
- Authors
Cheng, Chao; Ma, Xiaotu; Yan, Xiting; Sun, Fengzhu; Li, Lei M
- Abstract
Characterizing the dynamic regulation of gene expression by time course experiments is becoming more and more important. A common problem is to identify differentially expressed genes between the treatment and control time course. It is often difficult to compare expression patterns of a gene between two time courses for the following reasons: (1) the number of sampling time points may be different or hard to be aligned between the treatment and the control time courses; (2) estimation of the function that describes the expression of a gene in a time course is difficult and error-prone due to the limited number of time points. We propose a novel method to identify the differentially expressed genes between two time courses, which avoids direct comparison of gene expression patterns between the two time courses.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 21, p2650
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl451