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- Title
Transcript mapping with high-density oligonucleotide tiling arrays.
- Authors
Huber, Wolfgang; Toedling, Joern; Steinmetz, Lars M
- Abstract
High-density DNA tiling microarrays are a powerful tool for the characterization of complete transcriptomes. The two major analytical challenges are the segmentation of the hybridization signal along genomic coordinates to accurately determine transcript boundaries and the adjustment of the sequence-dependent response of the oligonucleotide probes to achieve quantitative comparability of the signal between different probes.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 16, p1963
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl289