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- Title
Automatic clustering of orthologs and inparalogs shared by multiple proteomes.
- Authors
Alexeyenko, Andrey; Tamas, Ivica; Liu, Gang; Sonnhammer, Erik L L
- Abstract
The complete sequencing of many genomes has made it possible to identify orthologous genes descending from a common ancestor. However, reconstruction of evolutionary history over long time periods faces many challenges due to gene duplications and losses. Identification of orthologous groups shared by multiple proteomes therefore becomes a clustering problem in which an optimal compromise between conflicting evidences needs to be found.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 14, pe9
- ISSN
1367-4811
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl213