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- Title
A simple implementation of a normal mixture approach to differential gene expression in multiclass microarrays.
- Authors
McLachlan, G J; Bean, R W; Jones, L Ben-Tovim
- Abstract
An important problem in microarray experiments is the detection of genes that are differentially expressed in a given number of classes. We provide a straightforward and easily implemented method for estimating the posterior probability that an individual gene is null. The problem can be expressed in a two-component mixture framework, using an empirical Bayes approach. Current methods of implementing this approach either have some limitations due to the minimal assumptions made or with more specific assumptions are computationally intensive.
- Publication
Bioinformatics (Oxford, England), 2006, Vol 22, Issue 13, p1608
- ISSN
1367-4803
- Publication type
Journal Article
- DOI
10.1093/bioinformatics/btl148